jQuery Page Layout Manager

Rather than use the iframe itself as a layout 'pane', you could also
put the iframe 'inside' a regular pane-div. Since the pane-div has a
width and height set, all you need is:

<iframe width="100%" height="100%" ...>

This will auto-size the iframe to fit within the inner-dimensions of
the pane - ie, inside the padding.

jQuery Page Layout Manager

Demo

Left / Right Panes


South / North Panes